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Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery (RECR-CABG)

N

Northern State Medical University

Status

Completed

Conditions

Recruitment
Hypoxemia

Treatments

Procedure: Alveolar recruitment

Study type

Interventional

Funder types

Other

Identifiers

NCT01457651
RECR-CABG-2010

Details and patient eligibility

About

The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism. The investigators compare three different types of alveolar recruitment in patient after cardiac surgery, to reveal which one is better.

Full description

The study compares three different approaches to alveolar recruitment maneuvers in the immediate postoperative period after off-pump coronary bypass grafting.

Enrollment

76 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age between 18 and 75
  • Off-pump coronary artery bypass grafting
  • Possibility to discontinue respiratory support in the first day after intervention

Exclusion criteria

  • Signs of ARDS
  • COPD in decompensation phase
  • Requirement for inotropic support(epinephrine >0,1 mcg/kg/hr)
  • Bronchiectases
  • Pregnancy
  • Morbid obesity
  • Aortic aneurism
  • AMI in previous month

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

76 participants in 4 patient groups

Recruitment 40x40
Active Comparator group
Description:
The group where recruitment is performed by increase in airway pressure up to 40 cm H2O for 40 seconds
Treatment:
Procedure: Alveolar recruitment
Recruitment PEAK40
Active Comparator group
Description:
Increase in peak airway pressure up to 40 cm H2O during tidal ventilation
Treatment:
Procedure: Alveolar recruitment
Recruitment 15x300
Active Comparator group
Description:
Recruitment by increase in airway PEEP up to 15 cm H2O for 300 sec
Treatment:
Procedure: Alveolar recruitment
No recruitment
Active Comparator group
Description:
No recruitment is performed: standard respiratory support.
Treatment:
Procedure: Alveolar recruitment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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