Comparison of Four Different Recruitment Maneuvers in Patients After Coronary Surgery (RECR-CABG)

Northern State Medical University

Status: Completed

Conditions: Recruitment; Hypoxemia

Treatments: Procedure: Alveolar recruitment

Study type: Interventional

Funder types: Other

Identifiers

NCT01457651

RECR-CABG-2010

Details and patient eligibility

About

The risk of respiratory failure after cardiac surgery is high, and it may result in many complications. The maneuver of alveolar recruitment may improve the oxygen transport in the human organism. The investigators compare three different types of alveolar recruitment in patient after cardiac surgery, to reveal which one is better.

Full description

The study compares three different approaches to alveolar recruitment maneuvers in the immediate postoperative period after off-pump coronary bypass grafting.

Enrollment: 76 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 75
• Off-pump coronary artery bypass grafting
• Possibility to discontinue respiratory support in the first day after intervention

Exclusion criteria

• Signs of ARDS
• COPD in decompensation phase
• Requirement for inotropic support(epinephrine >0,1 mcg/kg/hr)
• Bronchiectases
• Pregnancy
• Morbid obesity
• Aortic aneurism
• AMI in previous month

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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76 participants in 4 patient groups

Recruitment 40x40

Active Comparator group

Description:

The group where recruitment is performed by increase in airway pressure up to 40 cm H2O for 40 seconds

Treatment:

Procedure: Alveolar recruitment

Recruitment PEAK40

Active Comparator group

Description:

Increase in peak airway pressure up to 40 cm H2O during tidal ventilation

Treatment:

Procedure: Alveolar recruitment

Recruitment 15x300

Active Comparator group

Description:

Recruitment by increase in airway PEEP up to 15 cm H2O for 300 sec

Treatment:

Procedure: Alveolar recruitment

No recruitment

Active Comparator group

Description:

No recruitment is performed: standard respiratory support.

Treatment:

Procedure: Alveolar recruitment