Comparison of Fractionated Versus Bolus Administration of Different Doses of Hyperbaric Bupivacaine Combined With Opioids in Spinal Anesthesia for Caesarean Section

Bogomolets National Medical University

Status: Completed

Conditions: Spinal Anesthesia for Cesarean Section

Treatments: Procedure: Fractionated anesthesia; Procedure: Bolus anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT07249814

196

Details and patient eligibility

About

This study aimed to compare the effectiveness and safety of fractionated versus bolus administration of different doses of hyperbaric bupivacaine (0.06 and 0.07 mg/cm height) combined with opioids in spinal anesthesia for cesarean section, with detailed evaluation of maternal hemodynamic effects, block characteristics and side effects.

Enrollment: 99 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• singleton full-term pregnancy scheduled for cesarean section under spinal anesthesia
• ASA physical status II-III
• age 18-50 years
• height from 140 to 180 cm
• body weight from 40 to 130 kg

Exclusion criteria

• patient refusal
• contraindications to spinal anesthesia
• allergy to amide-type local anesthetics

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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99 participants in 3 patient groups

Bolus bupivacaine (0.07 mg/cm)

Active Comparator group

Treatment:

Procedure: Bolus anesthesia

Fractionated bupivacaine (0.07 mg/cm)

Experimental group

Treatment:

Procedure: Fractionated anesthesia

Fractionated bupivacaine (0.06 mg/cm)

Active Comparator group

Treatment:

Procedure: Fractionated anesthesia