Comparison of Genomic and Transcriptomic Patterns Between CTC and Metastatic Tumormetastatic Tumor

Samsung Medical Center

Status: Unknown

Conditions: NSCLC Stage IV; NSCLC Stage IIIB

Treatments: Diagnostic Test: cohort study

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04932343

IRB 2019-07-101

Details and patient eligibility

About

This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.

Enrollment: 20 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All subjects need to sign the informed consent form
• All subjects have non-small cell lung cancer which suspected on chest CT or confirmed pathologically preoperatively
• Treatment naïve advanced lung cancer (including extensive stage IIIb and stage IV)
• Patients who were suitable to provide enough metastatic tumor tissue and blood (30ml) for the single cells sequencing

Exclusion criteria

• Patients with previous history of lung cancer
• Have been undergone chemotherapy or radiotherapy due to non-small call lung cancer
• Have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix within 5 years before enrollment