Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction

Metropolitan College

Status: Enrolling

Conditions: Overweight; Adiposity; Overweight and Obesity

Treatments: Behavioral: Genotype-Based Dietary Counseling; Behavioral: Standard Dietary Counseling

Study type: Interventional

Funder types: Other

Identifiers

NCT07368777

001

Details and patient eligibility

About

This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.

Enrollment: 88 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged ≥18 years
• Body mass index (BMI) ≥25 kg/m²
• Greek-speaking (able to read and understand Greek and provide informed consent)
• Willing and able to participate in dietary counseling and study assessments for the duration of the study

Exclusion criteria

• Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
• Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
• Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
• Pregnancy or lactation
• Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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88 participants in 2 patient groups

Genotype-Based Dietary Counseling

Experimental group

Description:

Participants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period.

Treatment:

Behavioral: Genotype-Based Dietary Counseling

Standard Dietary Counseling

Active Comparator group

Description:

Participants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information.

Treatment:

Behavioral: Standard Dietary Counseling