Comparison of HFNC and COT to Diaphragm Function of Post-upper Abdominal Surgery Patients

University of Indonesia (UI)

Status: Completed

Conditions: Post Abdominal Surgery

Treatments: Procedure: HFNC; COT

Study type: Interventional

Funder types: Other

Identifiers

NCT04059614

IndonesiaUAnes028

Details and patient eligibility

About

This study aims to compare diaphragm thickness, air lung distribution, and several clinical and laboratory parameters on post abdominal surgery patients with conventional oxygen therapy vs high-flow nasal cannula

Full description

"Approval from Ethical Committee of Faculty of Medicine Universitas Indonesia was acquired prior conducting the study. Subjects were recruited using consecutive sampling method. Subjects underwent upper-abdominal surgery were screened. Eligible and consented subjects were randomized into intervention group (high-flow nasal cannula) and control group (conventional oxygen therapy). Subject and operation characteristics were recorded prior to intervention.

Clinical parameters (vital signs, Borg Score, ICON) were recorded in 10 specific times. diaphragm thickness data using abdominal ultrasonography (USG) and air lung distribution data using Electrical Impedance Tomography were collected in 7 specific times while lactate and blood gas analysis were done 4 times. "

Enrollment: 66 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients from 18 - 65 yrs old,
• American Society of Anaesthesia (ASA) status I-III,
• BMI < 30, patent airway,
• Measurement of Exercise Tolerance before Surgery (METS) Score > 4,
• P-POSSUM score <10%,
• agreed to the study

Exclusion criteria

• uncooperative subjects,
• DNR (do not resuscitate) patients,
• patients with tracheostomy, pleural effusion, pneumothorax or pulmonary atelectasis

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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66 participants in 2 patient groups

"High flow nasal cannula (HFNC)"

Active Comparator group

Description:

"HFNC group: those who receive high-flow nasal cannula therapy

Treatment:

Procedure: HFNC; COT

conventional oxygen therapy (COT)

Experimental group

Description:

COT group: those who receive conventional oxygen therapy group

Treatment:

Procedure: HFNC; COT