Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure

Hôpital de Verdun

Status: Completed

Conditions: Respiratory Failure; Chronic Obstructive Pulmonary Disease; Respiratory Insufficiency; Respiratory Tract Diseases; Pneumonia; COPD; COPD Exacerbation

Treatments: Device: Non-Invasive Ventilation; Device: High-Flow Nasal Cannula

Study type: Observational

Funder types: Other

Identifiers

NCT03443479

OF1

Details and patient eligibility

About

A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.

Full description

We will compare various clinically relevant outcomes in patients treated for type II (hypercapnic) acute respiratory failure (ARF) with either High-Flow Nasal Cannula (HFNC) or Non-Invasive Ventilation (NIV) in a general adult hospital.

All patients treated with HFNC were treated with an Optiflow device (Fisher&Paykel). Various Bilevel positive airway pressure (BiPAP) devices were used during the study period.

All ventilatory parameters were set according to the treating physicians' preferences.

Enrollment: 324 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients treated with respiratory failure not responding to conventional supplemental oxygen therapy
• Blood venous gas showing partial pressure of carbon dioxide>50 mmHg before beginning therapy with either NIV or HFNC

Exclusion criteria

• Lack of records of the primary outcome
• End-of-life care
• Lack of gas before the beginning of NIV or HFNC

Trial design

324 participants in 1 patient group

Patients with type II ARF

Description:

All patients with type II respiratory failure that were deemed by the treating physician to require ventilatory support either with non-invasive ventilation (NIV) or High-Flow Nasal Cannula (HFNC).

Treatment:

Device: High-Flow Nasal Cannula

Device: Non-Invasive Ventilation