Comparison of High Flow vs Standard Nasal Cannula in Children With Burns Under Sedoanalgesia

Zeliha Alicikus

Status: Completed

Conditions: Burns

Treatments: Other: High-flow nasal cannula; Drug: Propofol; Drug: midazolam, ketamine, propofol; Other: Conventional Nasal Cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT06663293

B.10.1.TKH.4.34.H.GP.0.01-93

Details and patient eligibility

About

The aim of this study is to investigate the positive effects of high-flow oxygen therapy on the reduction of airway adverse events and recovery time compared to conventional nasal oxygen therapy in pediatric burns treated with procedural sedoanalgesia.

Full description

High flow nasal cannula oxygenation (HFNCO) has gained popularity in pediatric anesthesia practice. The basic mechanism of HFNCO involves reducing metabolic cost and work of breathing, decreasing nasopharyngeal resistance, and improving gas conditioning and secretion clearance. Heating and humidifying the oxygen administered make it easier for patients to tolerate high flow. The flow rate can be adjusted for all age groups. However, there are no studies in the literature investigating the effectiveness of HFNCO during procedural sedation in pediatric burn patients.

This randomized prospective study was performed in 50 patients aged 1-14 years in the pediatric burn unit. Patients were divided into two groups as Group HFO: High flow oxygen (n: 25) and Group NC: nasal cannula oxygen (n: 25). Age, sex, burn percentage, concomitant diseases, ASA score, BMI (body mass index), respiratory and hemodynamic parameters, recovery time and presence of complications during sedoanalgesia were recorded.

Enrollment: 50 patients

Sex: All

Ages: 1 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 1 and 14 years
• ASA risk groups 1-3
• Second-degree burns covering more than 10% of the total body surface area, or third- and fourth-degree burns covering more than 2% of the total body surface area, burns involving the face, hands, feet, genital area, perineum, or major joints, electrical burns, and chemical burns.

Exclusion criteria

• Under 1 year of age or over 14 years of age
• ASA score above 3
• Having restrictive or obstructive chronic respiratory diseases, active upper or lower respiratory infections, first-degree burns, and burns to the nasal area or respiratory tract.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Conventional Nasal Cannula Oxygen group

Placebo Comparator group

Description:

Participants received low flow oxygen therapy through a conventional nasal cannula. The initial flow rate for nasal cannula oxygen was set at 3 L/min. In cases of hypoxia, the oxygen concentration was adjusted by increasing the flow rate by 1 to 2 L/min.

Treatment:

Other: Conventional Nasal Cannula

Drug: Propofol

Drug: midazolam, ketamine, propofol

High-flow Nasal Cannula Oxygen Group

Active Comparator group

Description:

Participants received nasal high flow therapy delivered by AIRVO™ 2 (Fisher and Paykel Healthcare Systems, New Zealand) along with single-use nasal oxygen cannulas.

Treatment:

Drug: Propofol

Drug: midazolam, ketamine, propofol

Other: High-flow nasal cannula