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Comparison of High Versus Low Bicarbonate Hemodialysis

Albert Einstein College of Medicine logo

Albert Einstein College of Medicine

Status

Completed

Conditions

Chronic Kidney Disease
Metabolic Acidosis
End-stage Renal Disease

Treatments

Other: Low Bicarbonate

Study type

Interventional

Funder types

Other

Identifiers

NCT02098356
2012-480

Details and patient eligibility

About

This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens.

Full description

This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens. These parameters will be assessed in patients currently receiving high-bicarbonate hemodialysis as part of usual care. They will then be switched to a lower bicarbonate prescription, after which these parameters will be reassessed. The study will also examine changes in inflammatory markers, glycemic control, ketogenesis, and lipolysis.

Enrollment

7 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age >18
  • Receiving chronic thrice-weekly conventional hemodialysis for at least 6 months

Exclusion criteria

  • Use of oral alkali within the previous month
  • Hospitalization within the previous month
  • Inability to provide written informed consent
  • Plans for kidney transplant in the next 2 months
  • Planned change in phosphate binder therapy within the next month
  • Pregnancy, or planned pregnancy in the next 2 months

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

7 participants in 1 patient group

Low bicarbonate
Experimental group
Description:
Low bicarbonate hemodialysis - 30 mEq/L dialysate bicarbonate
Treatment:
Other: Low Bicarbonate

Trial documents
1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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