Comparison of High Versus Low Bicarbonate Hemodialysis
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Details and patient eligibility
About
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens.
Full description
This study will compare hemodialysis treatment with a standard, high-bicarbonate dialysis bath versus a lower bicarbonate dialysis bath, and will compare intradialytic acid-base changes and overall control of metabolic acidosis with the 2 treatment regimens. These parameters will be assessed in patients currently receiving high-bicarbonate hemodialysis as part of usual care. They will then be switched to a lower bicarbonate prescription, after which these parameters will be reassessed. The study will also examine changes in inflammatory markers, glycemic control, ketogenesis, and lipolysis.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Age >18
- Receiving chronic thrice-weekly conventional hemodialysis for at least 6 months
Exclusion criteria
- Use of oral alkali within the previous month
- Hospitalization within the previous month
- Inability to provide written informed consent
- Plans for kidney transplant in the next 2 months
- Planned change in phosphate binder therapy within the next month
- Pregnancy, or planned pregnancy in the next 2 months
Trial design
Primary purpose
Allocation
Interventional model
Masking
7 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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