Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

Bezmialem Vakif University

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Biological: Hyaluronic acid injection; Biological: Platelet-rich plasma injection

Study type: Interventional

Funder types: Other

Identifiers

NCT03761472

71306642-050.01.04-

Details and patient eligibility

About

This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee osteoarthritis.

Full description

Platelet-rich plasma and hyaluronic acid injections are both popular treatments and commonly used for treatment of knee osteoarthritis. Even though there are many studies investigating the effectiveness of these treatments, the results are mostly qualitative. Also there are a few studies comparing these two treatment modalities. In this study the investigators aim to compare these modalities both for self-reported data (pain, physical function) and objective measurement data (femoral cartilage thickness via ultrasonography). Patients with unilateral osteoarthritis/unilateral complaint will be included in the study. Unaffected side will be controls for each group.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject is able to consent
• Subject meets Osteoarthritis Research Society International (OARSI) criteria for knee osteoarthritis
• Subject has radiographic Kellgren-Lawrence grade 2-3 osteoarthritis
• Unilateral osteoarthritis/complaint

Exclusion criteria

• Past or actual knee infection
• History of surgery, fracture on knee
• Collagen tissue disease
• Systemic inflammatory disease (rheumatoid arthritis, spondyloarthritis etc.)
• Systemic diseases (diabetes, hematologic diseases, endocrinopathies, renal failure, liver failure)
• Knee injection in past 6 months
• Immunodeficiency
• Pregnant/breastfeeding
• Malignancy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 4 patient groups

Hyaluronic acid injection

Active Comparator group

Description:

Hyaluronic acid 48 mg 2.0% in 2 ml solution, once initially.

Treatment:

Biological: Hyaluronic acid injection

Platelet-rich plasma injection

Active Comparator group

Description:

Platelet-rich plasma 5 ml, once initially

Treatment:

Biological: Platelet-rich plasma injection

Unaffected side Hyaluronic acid

No Intervention group

Description:

Unaffected sides of the patients will be controls for hyaluronic acid group, no intervention.

Unaffected side Platelet-rich plasma

No Intervention group

Description:

Unaffected sides of the patients will be controls for Platelet-rich plasma group, no intervention.