Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema

Hacettepe University

Status and phase: Completed; Phase 4

Conditions: Edema; Infection, Surgical Site; Trismus; Pain

Treatments: Drug: Hyaluronidase Injection mesomedica; Drug: Dexamethasone dekort

Study type: Interventional

Funder types: Other

Identifiers

NCT05466604

YDU/2019//74-921

Details and patient eligibility

About

The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection. For this purpose, 60 participants with symmetrical mandibular wisdom teeth enrolled the present study. All measurements and evaluations were performed before and 1, 2, 3, and 7 days later the operation.

Enrollment: 60 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• symmetrical mandibular wisdom teeth with bone retention
• patients who are signed informed consent and acceptance of study involvement forms

Exclusion criteria

• existence of any systemic disease
• existence of any periodical drug intake
• existence of difference in operation times of right and left impacted wisdom teeth extractions more than 5 minutes
• existence of pregnancy
• existence of breastfeeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 4 patient groups

hyaluronidase

Experimental group

Treatment:

Drug: Hyaluronidase Injection mesomedica

hyaluronidase control

No Intervention group

dexamethasone

Experimental group

Treatment:

Drug: Dexamethasone dekort

dexamethasone control

No Intervention group