Comparison of Hyperbaric Prilocaine With Chloroprocaine for Intrathecal Anaesthesia in Day Case Knee Arthroscopy

Centre Hospitalier Universitaire Saint Pierre

Status and phase: Completed; Phase 4

Conditions: Spinal Anesthesia; Knee Arthroscopy

Treatments: Drug: Hyperbaric prilocaine; Drug: Isobaric 2-chloroprocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03038958

AK160324627AD

Details and patient eligibility

About

This study compares intrathecal 1% plain chloroprocaine with intrathecal 2% hyperbaric prilocaine for patients undergoing ambulatory knee arthroscopy in terms of efficacy and side effects

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiology physical status (ASA) ≤ III
• Age 18-80 year
• Height between 160 and 185 cm
• Signed informed consent obtained prior to any study specific assessments and procedures

Exclusion criteria

• Cardiac pathology (such as Heart failure, Aortic stenosis)
• Coagulation disorders (INR>1.3, platelet < 80 000/mm3)
• Known allergy to local anaesthetics
• Disagreement of the patient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Isobaric 2-chloroprocaine

Active Comparator group

Description:

The 50 mg dose of isobaric 2-chloroprocaine will be administered to patients undergoing ambulatory knee arthroscopy

Treatment:

Drug: Isobaric 2-chloroprocaine

Hyperbaric prilocaine 2%

Active Comparator group

Description:

The dose of 50 mg of Hyperbaric prilocaine 2% will be administered to patients undergoing ambulatory knee arthroscopy

Treatment:

Drug: Hyperbaric prilocaine