Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Coronary Artery Disease; Myocardial Ischemia

Treatments: Other: FFR via peripheral venous line; Other: FFR via central venous line

Study type: Interventional

Funder types: Other

Identifiers

NCT01070420

D-0910-002-062

Details and patient eligibility

About

The purpose of this study is to evaluate the safety and effectiveness of the peripheral IV continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central IV continuous infusion method.

Enrollment: 66 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• non -infarct related, patients with moderate coronary artery stenosis
• normal ejection fraction on echocardiogram

Exclusion criteria

• infarct-related arteries or clinically unstable state
• collateral blood flow to the target vessel is shown
• atrioventricular block on electrocardiogram
• reduced ejection fraction(<50%) or left ventricular hypertrophy on echocardiography
• contraindication of adenosine

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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66 participants in 2 patient groups

FFR via central venous line

Active Comparator group

Treatment:

Other: FFR via central venous line

FFR via peripheral vein

Experimental group

Treatment:

Other: FFR via peripheral venous line