Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

Medical University of Vienna

Status: Completed

Conditions: Immunoglobulin A

Treatments: Drug: Anti-Bacterial Agents

Study type: Observational

Funder types: Other

Identifiers

NCT02912520

ORV001

Details and patient eligibility

About

Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• endotracheal intubation
• antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months

Exclusion criteria

• active infection
• pregnancy
• immunodeficiency

Trial design

20 participants in 2 patient groups

Patients with antibiotic therapy

Description:

Patients with antibiotic therapy for 2 weeks.

Treatment:

Drug: Anti-Bacterial Agents

Patients without antibiotic therapy

Description:

Patients without any antibiotic therapy in the last 3 months.