Comparison of Image Quality Between "Double Low Dose" Liver CT and Standard Liver CT

Seoul National University

Status: Enrolling

Conditions: Colorectal Cancer; Metastasis to Liver

Treatments: Diagnostic Test: Standard dose CT; Diagnostic Test: Double low dose CT

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05790590

SNUH-2022-3274

Details and patient eligibility

About

In patients with malignancies, contrast-enhanced abdominal CT (hereafter abdominal CT) plays an important role in detecting carcinoma recurrence and assessing treatment response. In this study, we aim to investigate whether such a "double low" dose CT is feasible in patients with liver metastases of colorectal cancer using a vendor-agnostic artificial intelligence-based noise reduction and contrast enhancement software.

Enrollment: 176 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• colorectal cancer (CRC) patients
• on surveillance or monitoring for liver metastasis (of CRC)

Exclusion criteria

• any relative or absolute contra-indication of CECT
• diffuse infiltrative type of liver metastasis or on monitoring for too many liver lesions

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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176 participants in 2 patient groups

Standard dose CT

Active Comparator group

Description:

Standard dose protocol CT using standard radiation dose (120 kVp) and standard dose of contrast media, and reconstructed with commercially available reconstruction algorithm of the CT scanner.

Treatment:

Diagnostic Test: Standard dose CT

Double low dose CT

Experimental group

Description:

Double low dose protocol CT using low radiation dose (120 kVp \& 70% of reference mAs of standard dose CT) and low dose of contrast media, and reconstructed with commercially available vendor-agonistic AI-based software.

Treatment:

Diagnostic Test: Double low dose CT