Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain

Clinique du Sport, Bordeaux Mérignac

Status: Enrolling

Conditions: Herniated Disc

Treatments: Procedure: Epidural platelet-rich plasma injection; Procedure: Epidural Steroid Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07036445

2024-38-SBM

Details and patient eligibility

About

The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications.

This study aims to compare these two treatments over the long term (2 years).

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).

Exclusion criteria

• Patients with infections,
• Patients who have had previous percutaneous corticosteroid injections,
• Patients undergoing systemic corticosteroid treatment,
• Patients with immune deficiencies,
• Patients who are allergic to the contrast medium used,
• Pregnant or breastfeeding patients,
• Patients with a history of allergies to anesthetics or corticosteroids,
• Anticoagulant treatment or blood disorders, patients on antiplatelet therapy
• Taking NSAIDs within two weeks prior to the procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

steroid treatment

Active Comparator group

Treatment:

Procedure: Epidural Steroid Injection

platelet-rich plasma treatment

Experimental group

Treatment:

Procedure: Epidural platelet-rich plasma injection