Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment

Nishtar Medical University

Status and phase: Not yet enrolling; Phase 4

Conditions: Keloid Scars

Treatments: Drug: Verapamil Injection; Drug: Triamcinolone Acetonide 1 ml of 40 mg/mL suspension

Study type: Interventional

Funder types: Other

Identifiers

NCT06897969

21467/NMU

Details and patient eligibility

About

This study aims to compare the efficacy of intralesional triamcinolone and verapamil in patients presenting with keloid at our local setting. The results will guide us towards better management of keloids by choosing the more appropriate treatment. Adequate treatment will reduce significant emotional and physical distress in patients. We hypothesized that mean reduction in Vancouver Scar Score is higher in triamcinolone acetonide group compared to verapamil after three months of treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 10 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• size of keloid1-5 cm,
• on any site of the body,
• duration less then five years and
• baseline Vancouver scar score of more the or equal to 5

Exclusion criteria

• Pregnant or lactating women,
• family history of keloids,
• acromegaly, and
• congestive cardiac diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Verapamil Treatment

Active Comparator group

Description:

One ml (2.5 mg) of Intralesional Verapamil Injection will be administered monthly. The injections will be administered with an insulin syringe of 27-gauge needle. Administration of the treatment medication will be continued till the keloid is flattened or TOTAL DURATION of three months.

Treatment:

Drug: Verapamil Injection

Triamcinolone Treatment

Experimental group

Description:

Intralesional Triamcinolone acetonide (40mg) will be administered monthly. The injections will be administered with an insulin syringe of 27-gauge needle. Administration of the treatment medication will be continued till the keloid is flattened or TOTAL DURATION of three months.

Treatment:

Drug: Triamcinolone Acetonide 1 ml of 40 mg/mL suspension