Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine

RESnTEC, Institute of Research

Status: Completed

Conditions: LAPAROSCOPIC CHOLECYSTECTOMY

Treatments: Drug: Bupivacaine injection; Drug: Dexmedetomidine injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06560892

DRQAZIANEESBVH

Details and patient eligibility

About

For patients with symptomatic cholelithiasis, laparoscopic cholecystectomy (LC) is a customary procedure for treatment these days. After LC, patients may experience considerable pain. This study was performed with the objective of comparing the mean duration of analgesia of intraperitoneal bupivacaine with dexmedetomidine to intraperitoneal bupivacaine alone in patients undergoing laparoscopic cholecystectomy.

Enrollment: 68 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of either gender
• Aged between 20 and 70 years
• ASA (American Society of Anesthesiologists Classification) physical status I and II
• Undergoing Laparoscopic Cholecystectomy under general anesthesia

Exclusion criteria

• Patients sensitive to local anesthetics
• Patients with acute cholecystitis, choledocholithiasis, or ascending cholangitis (temperature≥38.6°C, serum bilirubin≥1.2mg/dl, and ultrasound showing common bile duct diameter of ≥1cm).
• Patients with uncontrolled diabetes (FBS≥110 mg/dl)
• Uncontrolled blood pressure (SBP≥140 mmHg)
• Ischemic heart disease (EF≤40%)
• Pulmonary dysfunction (FEV≤70 percent of normal)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

68 participants in 2 patient groups

Bupivacaine group

Experimental group

Description:

Patients received intraperitoneal bupivacaine 50 ml 0.25% + 5 ml normal saline

Treatment:

Drug: Bupivacaine injection

Bupivacaine + Dexmedetomidine group

Experimental group

Description:

Patients were given intraperitoneal bupivacaine 50 ml 0.25% + dexmedetomidine 1 μg/kg with normal saline 5 ml

Treatment:

Drug: Dexmedetomidine injection

Drug: Bupivacaine injection