Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Acute Nonarteritic Anterior Ischemic Optic Neuropathy

Treatments: Other: placebo; Drug: Avastin and Triamcinolone

Study type: Interventional

Funder types: Other

Identifiers

NCT01330524

8749

Details and patient eligibility

About

In this study 16 Patients diagnosed with Nonarteritic Anterior Ischemic Optic Neuropathy(NSION) who had a sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn in less than 30 days without exclusion criteria are randomly divided in two groups 1) control 2) case. In case group Avastin and Triamcinolone will be injected trough vitreal and placebo will be injected in control group. BCVA and Visual field will be then measured in these two groups.

Enrollment: 16 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn (<30 days)

Exclusion criteria

• Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy)
• Neurologic defect
• Abnormal ESR, CRP, any history of retina or vitreal surgery
• Severe corneal opacity which makes retina examination impossible

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups, including a placebo group

Avastin and Triamcinolone

Active Comparator group

Treatment:

Drug: Avastin and Triamcinolone

Placebo

Placebo Comparator group

Treatment:

Other: placebo