Comparison of Intubating Condition of the Mcgrath Videolaryngoscope With and Without Muscle Relaxant

Prince of Songkla University

Status and phase: Completed; Phase 1

Conditions: Muscle Relaxant

Treatments: Device: Videolaryngoscope

Study type: Interventional

Funder types: Other

Identifiers

NCT02575716

PSU-561330812

Details and patient eligibility

About

The objective of this study was to evaluate intubating condition using the McGrath® VL Series 5, with and without muscle relaxant

Full description

Thirty-four patients with ASA classification I-II, who required oroendotracheal tube intubation, were studied in this prospective, double-blinded, randomized, clinical trial. Anesthesia was induced using fentanyl 1.5 mcg/kg, xylocaine 1.5 mg/kg and propofol 3 mg/kg. Patients were randomly assigned to one of the two groups to receive either rocuronium 0.6 mg/kg or saline intravenously. The Mcgrath® VL intubation was initiated after 90s, when the patients were fully relaxed. The primary outcome was to compare tracheal intubating conditions between two groups. The secondary outcomes were the success rate in the first attempt intubation, time to intubation, the required propofol dose for intubation and anesthetic complications. Statistical analyses were performed using the R program version 2.14.2. The level of statistical significance was set at p < 0.05.

Enrollment: 34 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-65 years old.
• ASA class I-II.
• Elective surgery required general anesthesia with oroendotracheal intubation

Exclusion criteria

• Suspected or known difficult airway.
• Patient with risk of aspiration with required of rapid sequence induction .
• Plan remained intubation.
• Allergic to drugs used in the study.
• Renal or hepatic disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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34 participants in 2 patient groups, including a placebo group

Muscle relaxant

Experimental group

Description:

Intubation with McGrath video laryngoscope after fentanyl 1.5 mcg/kg, xylocaine 1.5 mg/kg and propofol 3 mg/kg muscle relaxant use rocuronium 0.6 mg/kg

Treatment:

Device: Videolaryngoscope

Placebo

Placebo Comparator group

Description:

Intubation with McGrath video laryngoscope after fentanyl 1.5 mcg/kg, xylocaine 1.5 mg/kg and propofol 3 mg/kg placebo use NSS 0.6 mg/kg

Treatment:

Device: Videolaryngoscope