Comparison of IV Nalbuphine Versus Ibuprofen for Postoperative Pain Control in Cesarean Section

Muhammad Aamir Latif

Status: Completed

Conditions: Pain Management

Treatments: Drug: Ibuprofen; Drug: Nalbuphine

Study type: Interventional

Funder types: Other

Identifiers

NCT06594224

NishterMultan-1

Details and patient eligibility

About

The local data is insufficient to directly compare IV nalbuphine versus ibuprofen among people in this region. The findings of this study would add to the existing data and would be helpful for health providers to opt for a better option for postoperative pain relief following a cesarean section under general anesthesia.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parturient females
• Aged between 18-45 years
• Gestational age above 32 weeks
• ASA class I to II
• Anticipated hospital stay for at least 24 hours

Exclusion criteria

• Known allergy to the drugs being evaluated in this study
• Renal and/or hepatic impairment (as per medical record)
• History of bronchial asthma or history or risk of intracranial hemorrhage (as per medical record)
• Low platelets count (<70000) or with bleeding diathesis
• BMI above 30 kg/m2

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

IV Ibuprofen Group

Experimental group

Description:

Females in this group (n=40) were given 800 mg Ibuprofen in 200 cc normal saline intravenously at the time of arrival in the ward

Treatment:

Drug: Ibuprofen

IV Nalbuphine

Experimental group

Description:

Patients in this group received 20 mg nalbuphine in 200 cc normal saline IV at the time of arrival in the ward.

Treatment:

Drug: Nalbuphine