Comparison of IVF and ICSI in Human IVF

Semmelweis University

Status: Unknown

Conditions: Infertility

Treatments: Procedure: ICSI

Study type: Interventional

Funder types: Other

Identifiers

NCT03513913

SemmelweisU-003

Details and patient eligibility

About

In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment. Outcome of conventional IVF and intracytoplasmic sperm injection (ICSI) treatment will be compared in this study.

Enrollment: 600 estimated patients

Sex: Female

Ages: 18 to 48 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Infertile patients entering in vitro fertilization treatment At least 1 oocytes collected Semen sample is suitable for IVF and ICSI fertilization as well Number of oocytes collected is lower than 5 AND/OR female age is equal or more than 40 years

Exclusion criteria

Samen sample is not suitable for conventional IVF fertilization Previous conventional IVF treatment resulted in <50% fertilization rate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

600 participants in 2 patient groups

IVF

Experimental group

Description:

Oocytes fertilized by conventional in vitro fertilization (IVF) method

Treatment:

Procedure: ICSI

ICSI

Experimental group

Description:

Oocytes fertilized by intracytoplasmic sperm injection (ICSI) method

Treatment:

Procedure: ICSI