Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients

Ajou University School of Medicine

Status: Terminated

Conditions: Shock, Traumatic; Trauma

Treatments: Drug: Etomidate Injection 0.2 mg/kg; Drug: Ketamine injection 2 mg/kg

Study type: Interventional

Funder types: Other

Identifiers

NCT04120870

MED-OBS-19-294

Details and patient eligibility

About

In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.

Full description

In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.

Enrollment: 10 patients

Sex: All

Ages: 19 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 19~70
• Shock index ≥ 0.9
• Patients who need intubation regarding to Ajou trauma center protocol

Exclusion criteria

• during CPR
• CPR before hospital arrival
• Severe head trauma
• Steroid intake history

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Etomidate

Active Comparator group

Description:

The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg

Treatment:

Drug: Etomidate Injection 0.2 mg/kg

Ketamine

Experimental group

Description:

The induction agent of rapid sequence intubation is ketamine. 2 mg/kg

Treatment:

Drug: Ketamine injection 2 mg/kg