Comparison of Lidocaine-Prilocaine Combination and Vapocoolant for IV Cannulation Pain in the ED

Tehran University of Medical Sciences

Status and phase: Completed; Phase 3

Conditions: Pain

Treatments: Drug: Vapocoolant spray; Drug: Lidocaine-Prilocaine cream

Study type: Interventional

Funder types: Other

Identifiers

NCT04473820

9111215292

Details and patient eligibility

About

Hypothesis: Lidocaine-Prilocaine Combination is as effective as Vapocoolant in treating IV cannulation pain in the emergency department.

Full description

Lidocain-Prilocaine combination cream is two amide-type local anesthetics used for topical skin anesthesia. Vapocoolant spray is also another method for providing appropriate analgesia through crayoanesthetic mechanisms. Although there are some contraindications and adverse effects, these are widely used in the Emergency Department (ED) for IV cannulation pain.

Enrollment: 77 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Low acute patients who are waiting for the admission to the ED and require IV cannulation

Exclusion criteria

• Altered mental status
• Uncooperative patients
• Unable to communicate
• Known history of hypersensitivity reaction to cold or amid analgesics
• Analgesic usage in previous 6 hours
• No consent
• Emergent condition
• Pregnancy and lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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77 participants in 2 patient groups

Vapocoolant spray

Active Comparator group

Description:

Patients in this arm will receive vapocoolant spray before IV cannulation.

Treatment:

Drug: Vapocoolant spray

Lidocaine-Prilocaine cream

Active Comparator group

Description:

Patients in this arm will receive Lidocaine-Prilocaine cream before IV cannulation.

Treatment:

Drug: Lidocaine-Prilocaine cream