Comparison of Low and High Ligation in the Rectal Cancer

Wakayama Medical University

Status: Completed

Conditions: Rectal Cancer

Treatments: Procedure: preservation of nerve fibers around IMA; Procedure: resection of nerve fibers around IMA

Study type: Interventional

Funder types: Other

Identifiers

NCT00701012

WMU512

Details and patient eligibility

About

The purpose of this study is to evaluate the defecatory function when nerve fibers around the inferior mesenteric artery(IMA) and left colic artery(LCA) are preserved(so called low ligation ) or not(high ligation) in the rectosigmoid and rectal cancer surgery.

Full description

Fecal incontinence after anterior resection are often observed. Whether or not postoperative bowel function is influenced by the preservation of nerve fibers around the root of IMA and LCA (low ligation) is still unknown. So in this randomized controlled trial, we evaluate the efficacy of low ligation in terms of the bowel function.

Enrollment: 100 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• On the basis of whether anterior resection was anticipated at WMUH for rectosigmoid and rectal cancer, and appropriate informed consent was obtained.

Exclusion criteria

• Patients who could not respond to medical interview for own bowel function
• Patients without an informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

1

Experimental group

Description:

low ligation, which the IMA is ligated below the origin of the left colic artery

Treatment:

Procedure: preservation of nerve fibers around IMA

2

Active Comparator group

Description:

high ligation, which the IMA is ligated at its origin from the aorta

Treatment:

Procedure: resection of nerve fibers around IMA