Comparison of Lung Deposition With the Aeroneb Solo Adapter and a Standard Jet Nebulizer by SPECT-CT

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Healthy

Treatments: Other: Single photon emission computed tomography; Other: Planar scintigraphy; Device: Aeroneb Solo Adapter; Drug: Technetium-99m - Diethylenetriaminepentaacetic acid; Device: Opti-Mist Plus Nebulizer; Other: Spirometry

Study type: Interventional

Funder types: Other

Identifiers

NCT02298101

AeroSpect-01

Details and patient eligibility

About

Aeroneb Solo Adapter is a vibrating-mesh nebulizer Aeroneb Solo combined to a spacer specifically designed for spontaneously breathing patients. This device has not been investigated in vivo yet.

It's known that using a spacer during nebulization improves aerosol delivery. We hypothetized that lung deposition could be highly increased with the Aeroneb Solo Adapter in comparison to a standard jet nebulizer.

Enrollment: 6 patients

Sex: Male

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy respiratory function

Exclusion criteria

• Pulmonary disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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6 participants in 2 patient groups

Aeroneb Solo Adapter

Active Comparator group

Description:

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo Adapter

Treatment:

Device: Aeroneb Solo Adapter

Drug: Technetium-99m - Diethylenetriaminepentaacetic acid

Other: Spirometry

Other: Single photon emission computed tomography

Other: Planar scintigraphy

Standard Jet Nebulizer

Active Comparator group

Description:

Subjects inhaled radiolabelled aerosol via a standard jet nebulizer, the Opti-Mist Plus Nebulizer

Treatment:

Drug: Technetium-99m - Diethylenetriaminepentaacetic acid

Device: Opti-Mist Plus Nebulizer

Other: Spirometry

Other: Single photon emission computed tomography

Other: Planar scintigraphy