Comparison of Lysine Clonixinate, Ketorolac and Metamizole Sodium in Scorpion Stings

Mexican Red Cross

Status: Completed

Conditions: Analgesic; Scorpion Stings; Pain

Treatments: Diagnostic Test: Visual Analogue Scale for pain

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03943199

CRM-Alacran-2019

Details and patient eligibility

About

The cases of scorpion stings are matters of medical importance, where Mexico is considered as one of the main countries of such public health problem.

Full description

The states with the highest incidence of cases in 2018 were Jalisco with 47370 bite reports, Guerrero with 40672 cases and Guanajuato with 40331, according to the national epidemiological surveillance system.

Due to the high affinity on ion channels, where a cystine inhibitor BmP01, it is directed to the nociceptive ion channel TRPV1 to produce pain.Pain has been reported to occur in approximately 97% of patients They are seen in the emergency room.

Enrollment: 160 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of pain by scorpion stings
• Patients> 18 years old
• Clinical diagnosis of scorpion sting poisoning grade I, II and III.
• Chronic degenerative diseases (renal failure, hypertension, liver damage)

Exclusion criteria

• Patients who reject the continuation of medical treatment
• Patients who are transferred to a unit of second level of care.
• Patients with pharmacological treatment prior

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Triple Blind

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160 participants in 4 patient groups, including a placebo group

Metamizole sodium

Active Comparator group

Description:

1 gram intravenous, will be diluted in 0.9% physiological solution of 100 ml, applied for 30 minutes

Treatment:

Diagnostic Test: Visual Analogue Scale for pain

Ketorolac

Active Comparator group

Description:

60 milligrams intravenously, it will be added to 20 ml with 0.9% physiological solution, it will be applied for 5 minutes

Treatment:

Diagnostic Test: Visual Analogue Scale for pain

Lysine Clonixinate

Active Comparator group

Description:

100 milligram intravenously, diluted in 5% glucose solution of 100 ml, applied for 30 minutes

Treatment:

Diagnostic Test: Visual Analogue Scale for pain

Placebo

Placebo Comparator group

Description:

20 milliliters of 0.9% physiological solution, will be applied for 5 minutes.

Treatment:

Diagnostic Test: Visual Analogue Scale for pain