Comparison of Methods to Facilitate Rapid Sequence Intubation

Seoul National University

Status: Completed

Conditions: Intubating Condition

Treatments: Drug: rocuronium; Drug: Magnesium Sulfate; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT01479751

facilitating RSI

Details and patient eligibility

About

In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.

Full description

Patients are pretreated with Mg, ketamine, or priming dose Roc. Two groups do not receive pretreatment, but are given Roc 0.6 mg/kg or 0.9 mg/kg.

Enrollment: 110 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 - 65 years,
• ASA 1 - 2,
• patients scheduled for elective surgery under general anesthesia,
• BMI 18.5-24.9 kg/m2
• Mallampati class I-II

Exclusion criteria

• neuromuscular disorder,
• cardiac/hepatic/renal insufficiency,
• pregnant.
• anticipated difficult airway
• medications that influence neuromuscular transmission

Trial design

110 participants in 5 patient groups

ketamine

Experimental group

Description:

Patients receive ketamine 0.5 mg/kg 2 min before Roc injection.

Treatment:

Drug: Ketamine

priming

Experimental group

Description:

Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg.

Treatment:

Drug: rocuronium

Roc 0.9

No Intervention group

Description:

Patients receive Roc 0.9 mg/kg as an induction dose.

Control

No Intervention group

Description:

Patients receive Roc 0.6 mg/kg without any pretreatments of Mg, ketamine, or priming.

Mg

Experimental group

Description:

Patients receive magnesium sulfate (MgSO4) 50 mg/kg over 10 min before Roc injection.

Treatment:

Drug: Magnesium Sulfate