Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Central South University

Status: Unknown

Conditions: Sepsis

Treatments: Device: hemodynamic monitoring; Device: sublingual microcirculation,

Study type: Interventional

Funder types: Other

Identifiers

NCT05118646

202006141

Details and patient eligibility

About

Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Full description

Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock.

Intervention:

1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV > 68%).
2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.

Primary outcome:

(1)change in SOFA score at 72h (2)30-day mortality

Enrollment: 62 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients fulfilled the diagnostic criteria of septic shock.

Exclusion criteria

• declined to participate
• pregnant
• patients who were younger than 18 years old
• active bleeding
• septic shock is diagnosed for more than 4 hours
• patients are expected to be die within 24hours

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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62 participants in 2 patient groups

Microcirculation-oriented resuscitation group

Experimental group

Description:

The microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%).

Treatment:

Device: hemodynamic monitoring

Device: sublingual microcirculation,

Control group

Other group

Description:

The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.

Treatment:

Device: hemodynamic monitoring