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Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

C

Central South University

Status

Unknown

Conditions

Sepsis

Treatments

Device: hemodynamic monitoring
Device: sublingual microcirculation,

Study type

Interventional

Funder types

Other

Identifiers

NCT05118646
202006141

Details and patient eligibility

About

Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Full description

Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock.

Intervention:

  1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV > 68%).
  2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.

Primary outcome:

(1)change in SOFA score at 72h (2)30-day mortality

Enrollment

62 estimated patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients fulfilled the diagnostic criteria of septic shock.

Exclusion criteria

  • declined to participate
  • pregnant
  • patients who were younger than 18 years old
  • active bleeding
  • septic shock is diagnosed for more than 4 hours
  • patients are expected to be die within 24hours

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

62 participants in 2 patient groups

Microcirculation-oriented resuscitation group
Experimental group
Description:
The microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%).
Treatment:
Device: hemodynamic monitoring
Device: sublingual microcirculation,
Control group
Other group
Description:
The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters.
Treatment:
Device: hemodynamic monitoring

Trial contacts and locations

1

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Central trial contact

Lina Zhang, MD.

Data sourced from clinicaltrials.gov

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