Comparison of Microwave and Radiofrequency Ablation for Liver

Chinese PLA General Hospital (301 Hospital)

Status: Completed

Conditions: Hepatocellular Carcinoma

Treatments: Device: radiofrequency ablation; Device: microwave ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT02539212

939530

Details and patient eligibility

About

According to randomized controlled trial requirement, the therapeutic effectiveness of cooled-probe microwave ablation and radiofrequency ablation on early-stage hepatocellular carcinoma is compared to find a better approach for minimally invasive thermal ablation.

Full description

According to following enrollment standard, about >400 cases of biopsy-proved hepatocellular carcinoma(HCC) patients will be involved in the study. They will be treated with percutaneously microwave ablation (MWA) and radiofrequency ablation(RFA). The indications of patients enrolled in the study were as follows: tumor size ≤5cm in diameter, tumor number ≤3, Child-Pugh class A or B classification, no evidence of extrahepatic metastasis, vein or bile duct tumor embolus, and no any other anti-cancer treatment was accepted. MWA or RFA is selected for the patient according to the sequence of their visit to the hospital based on randomization number arrangement produced by SPSS 16.0 statistical software. The therapeutic effectiveness will be compared between two modalities.

Enrollment: 403 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• tumor size ≤5cm in diameter,
• tumor number ≤3,
• Child-Pugh class A or B classification,
• no evidence of extrahepatic metastasis,
• vein or bile duct tumor embolus, and
• no any other anti-cancer treatment

Exclusion criteria

• not meeting the inclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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403 participants in 2 patient groups

microwave ablation

Active Comparator group

Description:

microwave ablation

Treatment:

Device: microwave ablation

radiofrequency ablation

Active Comparator group

Description:

radiofrequency ablation

Treatment:

Device: radiofrequency ablation