Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Samsung Medical Center

Status: Completed

Conditions: Central Serous Chorioretinopathy

Study type: Observational

Funder types: Other

Identifiers

NCT00803517

2008-05-030

Details and patient eligibility

About

This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

Full description

1. Laser Group: extrafoveal focal leakage on FAG
2. PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center

Inclusion criteria

1. Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
2. Ability to maintain steady fixation for mfERG
3. Presence of abnormal dilated choroidal vasculature in ICGA
4. Symptom duration over 3 months

Exclusion criteria

1. previous PDT or laser treatment history
2. evidence of Choriinal neovascularization in FAG
3. other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

follow-up Visit

1)baseline 2)1month 3)3months 4)6 months

each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.

Enrollment: 24 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. CSC (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
2. Ability to maintain steady fixation for mfERG
3. Presence of abnormal dilated choroidal vasculature in ICGA
4. Symptom duration over 3 months

Exclusion criteria

1. Previous PDT or laser treatment history
2. Evidence of CNV in FAG
3. Other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

Trial design

24 participants in 2 patient groups

Photodynamic therapy (PDT)

Focal laser photocoagulation (focal)