Comparison of Multiple Oxygenation Targets With Different Oximeters in Chronic Obstructive Pulmonary Disease (COPD) and Non-COPD Patients- Impact on Oxygen Flows

Laval University

Status: Not yet enrolling

Conditions: Respiratory Disease; Pneumonia; Hypoxemia; COPD Exacerbation

Treatments: Device: Nellcor oximeter; Device: Nonin oximeter; Device: Masimo oximeter

Study type: Interventional

Funder types: Other

Identifiers

NCT05819164

2023-4002

Details and patient eligibility

About

The oximeter is an instrument for monitoring patients receiving oxygen therapy. It displays pulse oxygen saturation (SpO2), which is a reflection of arterial oxygen saturation (SaO2). An accurate SpO2 value is essential for optimal management of the O2 flow delivered to patients. Several factors can influence this measurement and the choice of ventilatory support: the type of oximeter used, skin pigmentation and the oxygenation goal.

The objective of our study is to evaluate the impact of the oxygenation goal and the oximeter used on oxygen flows in patients with COPD (or with hypercapnia, or at risk of hypercapnia) and in patients without COPD (in particular pneumonia, pulmonary fibrosis and other pathologies) Our hypothesis is that the SpO2 target and oximeter used will have an impact on oxygen flows and that these effects will be synergistic in these different populations.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 18 years old
• On conventional oxygen therapy with SpO2 between 88 and 100% with the usual oximeter and nasal cannula.
• SpO2 < 92% in ambient air with the usual oximeter

Exclusion criteria

• No availability of the SpO2 signal with the usual oximeter
• False nails or nail polish
• Severe anemia documented on the last blood count during the current hospitalization (Hb < 80g/L)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

40 participants in 5 patient groups

88% SpO2 target

Experimental group

Description:

During this periods , oxygen will be administered in manual titration to reach 88% of SpO2.

Treatment:

Device: Nellcor oximeter

Device: Masimo oximeter

Device: Nonin oximeter

90% SpO2 target

Experimental group

Description:

During this periods , oxygen will be administered in manual titration to reach 90% of SpO2.

Treatment:

Device: Nellcor oximeter

Device: Masimo oximeter

Device: Nonin oximeter

92% SpO2 target

Experimental group

Description:

During this periods , oxygen will be administered in manual titration to reach 92% of SpO2.

Treatment:

Device: Nellcor oximeter

Device: Masimo oximeter

Device: Nonin oximeter

94% SpO2 target

Experimental group

Description:

During this periods , oxygen will be administered in manual titration to reach 94% of SpO2.

Treatment:

Device: Nellcor oximeter

Device: Masimo oximeter

Device: Nonin oximeter

96% SpO2 target

Experimental group

Description:

During this periods , oxygen will be administered in manual titration to reach 96% of SpO2.

Treatment:

Device: Nellcor oximeter

Device: Masimo oximeter

Device: Nonin oximeter