Comparison of Norepinephrine and Ephedrine on Hypotension After Spinal Anesthesia in Parturients

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Hypotension; Obstetrical Complication of Anesthesia; Complications; Cesarean Section

Treatments: Drug: Norepinephrine; Drug: Ephedrine

Study type: Interventional

Funder types: Other

Identifiers

NCT02542748

XJH-A-2015-5-5-01

Details and patient eligibility

About

Incidence of hypotension is high in parturients after spinal anesthesia. Ephedrine could be used to treat hypotension but lead to lower fetal pH as well. This study is to compare the effects of norepinephrine and ephedrine on hypotension in parturients.

Full description

Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. Ephedrine could be used to treat hypotension but lead to lower fetal pH, which may be related to worse fetal outcome.Norepinephrine could improve the hypotension to the same extent as phenylephrine. In this study, we tend to compare the effects of norepinephrine and ephedrine on hypotension in parturients and on fetal acid status.

Enrollment: 66 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective cesarean section

Exclusion criteria

• Patients with severe pre-eclampsia
• Patients with contraindications for spinal anesthesia
• Patients with multiple pregnancy
• Patients with gestation <38w

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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66 participants in 2 patient groups

norepinephrine

Experimental group

Description:

norepinephrine is injected after spinal anesthesia

Treatment:

Drug: Norepinephrine

ephedrine

Other group

Description:

ephedrine is injected after spinal anesthesia

Treatment:

Drug: Ephedrine