Comparison of Oral vs Intravenous Iron Therapy for the Treatment of Postpartum Anemia

Shahida Islam Medical Complex

Status: Completed

Conditions: Postpartum Anaemia

Treatments: Drug: Ferrous Sulfate; Drug: Ferric Carboxy Maltose

Study type: Interventional

Funder types: Other

Identifiers

NCT07340450

SIMC-postpartumanemia-2025

Details and patient eligibility

About

Postpartum anemia is a common condition associated with adverse maternal outcomes. This study aimed to compare the effectiveness of oral iron therapy versus intravenous iron therapy in women with postpartum anemia.

Full description

This randomized, open-label, parallel-group study was conducted at Shahida Islam Medical College and Hospital, Lodhran, Pakistan. Women diagnosed with postpartum anemia who fulfilled the eligibility criteria were randomly allocated using a lottery method to receive either intravenous iron (ferric carboxymaltose) or oral iron therapy (ferrous sulfate). The primary outcome was the change in hemoglobin level from baseline to 6 weeks of follow-up.

Enrollment: 122 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All women with postpartum anaemia as per operational definition i.e Haemoglobin <11 g/dl at 24 hours after delivery (either caesarean or SVD).

2. Age 20-40 years.

3. BMI 19-25.

4. Pre-operative haemoglobin >10 g/dl.

5. Both primiparous and multiparous.

6. Both primigravida and multigravida.

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Exclusion criteria

1. Iron Intolerance or previous history of allergy to iron
2. Parenteral Iron hypersensitivity
3. Patients with thalassemia
4. Indication of blood transfusion
5. Patients with bleeding/ clotting disorders
6. Patients with postpartum haemorrhage
7. Patients with chronic diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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122 participants in 2 patient groups

Group A: Intravenous Iron Therapy

Experimental group

Description:

Participants received intravenous iron therapy for the treatment of postpartum anemia

Treatment:

Drug: Ferric Carboxy Maltose

Group B: Oral Iron Therapy

Experimental group

Description:

Participants received oral iron therapy for the treatment of postpartum anemia.

Treatment:

Drug: Ferrous Sulfate