Comparison Of Outcome Of Microneedling With Autologous PRP Vs Microneedling With Topical Insulin In Treatment Of Post Acne Atrophic Scars.

Jinnah Postgraduate Medical Centre

Status and phase: Completed; Phase 2

Conditions: ATROPHIC ACNE SCARS

Treatments: Drug: PRP( platelet rich plasma) and Insulin human

Study type: Interventional

Funder types: Other

Identifiers

NCT06002854

NO.F.2-81/2022-GENL/252/JPMC

Details and patient eligibility

About

Microneedling with topical INSULIN is a simple, effective tool for building body's new collagen layers and thus an alternative to all erosive techniques such as lasers, peels. The skin responds to fine punctures with the release of growth factors. 8 It is a safe procedure that can be performed in the office without complications, with a good cost-benefit because it is economically viable without any effect on patient's daily activities. 9

Enrollment: 50 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• postacne atrophic scars ≥ 2 on Goodman and Baron's acne scar-grading system
• Either gender.
• Age 20-50 years.

Exclusion criteria

• lactation and pregnancy
• skin cancers and infection
• photosensitivity like SLE ,XP
• use of RETINOIDS in last 6 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

GROUP A Microneedling with PRP(platelete rich plasma)

Experimental group

Treatment:

Drug: PRP( platelet rich plasma) and Insulin human

GROUP B Microneedling with topical INSULIN

Experimental group

Treatment:

Drug: PRP( platelet rich plasma) and Insulin human