Comparison of Outcomes Between Intraosseous Femoral and Tibial Injection in Simultaneous Bilateral Total Knee Arthroplasty Patients

Rajavithi Hospital

Status: Enrolling

Conditions: Pain, Postoperative

Treatments: Drug: Multimodal Intraosseous Tibial Injection; Drug: Multimodal Intraosseous Femoral Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06243575

149/66

Details and patient eligibility

About

In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient. Pain management after total knee arthroplasty TKA is an important consideration to improve patient outcomes and reduce length of stay. Periarticular injections of the knee are one of the techniques used to reduce pain after surgery. Studies have shown that compared to other methods of pain relief, they are effective and safe. At present, no studies to compare between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection in Simultaneous Bilateral TKA patients.

Enrollment: 20 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who will undergo bilateral Total knee Replacement due to osteoarthritis of both knees
• Used of a cemented, PS design TKA surgery.
• Able to give informed consent

Exclusion criteria

• Revision TKA
• History of previous knee or hip surgery
• History of allergic reaction or side effects to the drug that will be used in the experiment
• Underlying diseases of chronic kidney disease or chronic liver disease (Child Pugh B or C)
• Pregnancy
• History of coagulopathy or abnormal blood coagulation profile(INR >1.4 or aPTT ratio > 1.4)
• History of platelet dysfunction or platelet count < 140,0000/mm3
• History of Thromboembolism
• Use of Anticoagulants.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Multimodal Intraosseous Femoral Injection

Experimental group

Description:

Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in femoral canal

Treatment:

Drug: Multimodal Intraosseous Femoral Injection

Multimodal Intraosseous Tibial Injection

Experimental group

Description:

Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in tibial canal

Treatment:

Drug: Multimodal Intraosseous Tibial Injection