Comparison of Outcomes Between Parenteral and Enteral Nutrition

Tokyo University

Status: Completed

Conditions: Deglutition Disorders

Treatments: Device: Enteral nutrition; Device: Parenteral nutrition

Study type: Observational

Funder types: Other

Identifiers

NCT02512224

NCGG 25-11 (Other Grant/Funding Number)

MHLW H26-Special-047 (Other Grant/Funding Number)

MHLW H26-Policy-011

Details and patient eligibility

About

Short-term outcomes of parenteral and enteral nutrition for patients unable to eat normally were compared and analyzed.

Full description

Data were acquired from patients selected from a national inpatient database covering 1,057 hospitals in Japan. Participants had received artificial nutrition between April 2012 and March 2013, were 20 years or older, and did not have cancer. Participants were grouped into two groups: those receiving parenteral nutrition and those receiving enteral nutrition. The investigators performed one-to-one propensity-score matching between the groups. The primary outcome measurements were mortality rates at 30 and 90 days after the start of the procedure. The secondary outcomes were post-procedural complications, pneumonia, and sepsis. The investigators analyzed survival length of stay after the procedure using a Cox proportional hazards model.

Enrollment: 5,824 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• investigators selected participants aged 20 years or older who had undergone either parenteral nutrition by central venous port insertion or enteral nutrition by percutaneous endoscopic gastrostomy, percutaneous transesophageal gastrotubing, or ileostomy between April 1, 2012, and March 31, 2013. Patients who received both gastrostomy and central venous port insertion were assigned to the gastrostomy group.

Exclusion criteria

• investigators excluded participants who had been diagnosed with cancer.

Trial design

5,824 participants in 2 patient groups

Parenteral nutrition

Description:

investigators selected participants aged 20 years or older who had undergoneparenteral nutrition by central venous port insertion between April 1, 2012, and March 31, 2013.

Treatment:

Device: Parenteral nutrition

Enteral nutrition

Description:

investigators selected participants aged 20 years or older who had undergone enteral nutrition by percutaneous endoscopic gastrostomy, percutaneous transesophageal gastrotubing, or ileostomy between April 1, 2012, and March 31, 2013.

Treatment:

Device: Enteral nutrition