Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

College of Physicians and Surgeons Pakistan

Status: Active, not recruiting

Conditions: Irreversible Pulpitis

Treatments: Drug: Normal saline injection; Drug: Dexamathsone 4mg/ml associated with experimental arm

Study type: Interventional

Funder types: Other

Identifiers

NCT07233564

117-ERB/023

Details and patient eligibility

About

This randomized controlled trial aims to compare the effectiveness of supra periosteal injection of dexamethasone versus placebo in reducing post operative pain in teeth diagnosed with symptomatic irreversible pulpitis. A total of 44 patients will be randomly assigned into two groups: Group A will receive a supra periosteal injection of dexamethasone(4mg/ml), and Group B will receive a similar injection of normal saline as placebo. post operative pain will be assessed at 6hr,24hr and 48hr using a VAS Analogue Scale, with the final outcome measured at 24hrs. the study will help determine whether local dexamethasone injection is effective in minimizing postoperative pain

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients age 18 or above 18 year old (to have complete apex formation)
• Patient with normal periapical area (no pain on percussion).
• Patient who have not received any preoperative analgesic and antibiotic in last one month.

Exclusion criteria

• Pregnancy and Lactation because radiographs are contraindicated.
• Moderate to severe periodontal disease because teeth are not salvageable.
• Patient with nonvital teeth diagnose via cold test and EPT.
• Patient with known sensitivity to dexamethasone by history.
• Patients whose medical history include a history of certain illnesses, such as HIV, heart disease, or epilepsy (conditions that can affect a patient's rate of healing).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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44 participants in 2 patient groups, including a placebo group

Dexamethasone injection group

Experimental group

Description:

participant in this arm will receive a supraperiosteal injection of 4mg/ml dexamethasone at the mucobuccal fold prior to endodontic treatment for symptomatic irreversible pulpitis

Treatment:

Drug: Dexamathsone 4mg/ml associated with experimental arm

Saline injector(placebo) group

Placebo Comparator group

Treatment:

Drug: Normal saline injection