Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery

Yonsei University

Status: Completed

Conditions: Orthopedic Surgery

Treatments: Drug: palonosetron; Drug: palonosetron with dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02744508

4-2015-0232

Details and patient eligibility

About

Postoperative nausea and vomiting (PONV) is related with extended hospital day and risk factor of aspiration pneumonia. Postoperative patient controlled intravenous analgesia is related with postoperative nausea and vomiting. Selective 5-HT3 antagonist, Palonosetron, is the most recent medication for prevention of PONV. Purpose of our study is comparison of PONV preventive effect of palonosetron and combination of palonosetron and dexamethasone.

Enrollment: 202 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who are undergoing minor orthopedic surgery.
• IV patient controlled analgesia

Exclusion criteria

• 1. minority (0~19 year)
• patients who are belongs to ASA class 3 or more, and have underlying complicated cardiovascular or psychological disease.
• Steroid medication
• Diabetes Mellitus medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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202 participants in 2 patient groups

P group

Active Comparator group

Description:

Palonosetron group

Treatment:

Drug: palonosetron

PD group

Experimental group

Description:

Palonosetron and dexamethasone group

Treatment:

Drug: palonosetron with dexamethasone