Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty

Chung-Ang University Gwangmyeong Hospital

Status: Completed

Conditions: Postoperative Pain, Acute

Treatments: Drug: ketorolac tromethamine with nefopam hydrochloride; Drug: Fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT05861791

2210033049

Details and patient eligibility

About

Patients who undergoing total knee arthroplasty under spinal analgesia will be recruited and randomly assigned to the following two groups according to the regimen of PCA: (A) opioid group who receive only fentanyl citrate 1200mcg for continuous infusion drug, (B) non-opioid group who receive ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug. All the patients will receive additional fentanyl citrate as bolus injection drug if they need more analgesics postoperatively.

Enrollment: 98 patients

Sex: All

Ages: 60 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I-II
• undergoing elective total knee arthroplasty under spinal anesthesia

Exclusion criteria

• history of stomack ulceration
• increased ICP
• bronchial asthma
• allergy on aspirin, NSAIDs, Nefopam
• drug user of antiplatelet or anticoagulant

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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98 participants in 2 patient groups

opioid group

Experimental group

Description:

IV-PCA consisted of fentanyl

Treatment:

Drug: Fentanyl

non-opioid group

Active Comparator group

Description:

IV-PCA consisted of ketorolac and nefopam

Treatment:

Drug: ketorolac tromethamine with nefopam hydrochloride