Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

Kutahya Health Sciences University

Status: Unknown

Conditions: Fetal Growth Retardation

Treatments: Other: . Pesticide and Pharmaceutical analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05088148

Kutahya Health Sciences Uni

Details and patient eligibility

About

Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

Full description

The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the ages of 18-40 years
• Gestational age between 320/7 - 396/7 weeks
• Singleton pregnancy
• For the FGR group: estimated fetal weight <10th percentile
• For the control group: being healthy pregnant
• Intact amniotic membrane

Exclusion criteria

• Multiple pregnancies
• Cardiovascular disease
• Chronic hypertension
• Autoimmune disease
• Intrahepatic cholestasis of pregnancy
• Preeclampsia-eclampsia
• Sepsis
• Placenta accreta spectrum
• Abnormalities of placenta
• The chromosomal or congenital structural anomaly of the fetus
• Smoking
• BMI >30 kg/m2

Trial design

40 participants in 2 patient groups

Group 1: FGR group

Description:

Estimated fetal weight \<10th percentile

Treatment:

Other: . Pesticide and Pharmaceutical analysis

Group 2: Control group

Description:

Healthy pregnants who will give birth 37th and after gestational week

Treatment:

Other: . Pesticide and Pharmaceutical analysis