Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels

Antalya Training and Research Hospital

Status: Completed

Conditions: Prostatectomy

Treatments: Procedure: NGAL

Study type: Observational

Funder types: Other

Identifiers

NCT03607279

2016-118

Details and patient eligibility

About

The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.

Full description

Patients undergoing radical prostatectomy are at increased risk of acute kidney injury (AKI) because of intraoperative bleeding, obstructive uropathy and older age. In particular robot-assisted laparoscopic radical prostatectomy (RALP) which is in increasing demand as an alternative surgical option for retropubic radical prostatectomy (RRP) is associated with postoperative renal dysfunction because pneumoperitoneum during RALP can decrease cardiac output and renal perfusion. NGAL may become important for diagnosis of postoperative AKI after urogenital oncosurgery.

Enrollment: 66 patients

Sex: Male

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who undergo prostatectomy
• American Society of Anesthesiology (ASA) I-III

Exclusion criteria

• preexisting renal disease
• emergency surgery
• heart failure
• peripheral vascular disease

Trial design

66 participants in 2 patient groups

NGAL - retropubic radical prostatectomy

Description:

Plasma NGAL was determined at baseline, 6 and 12 hrs after induction of anaesthesia

Treatment:

Procedure: NGAL

NGAL - robotic radical prostatectomy

Description:

Plasma NGAL was determined at baseline, 6 and 12 hrs after induction of anaesthesia

Treatment:

Procedure: NGAL