Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients (ELSE)

University Hospital, Angers

Status: Unknown

Conditions: Acute Respiratory Distress Syndrome

Treatments: Other: Strategy 2; Other: Strategy 1

Study type: Interventional

Funder types: Other

Identifiers

NCT03281473

49RC17_0220

Details and patient eligibility

About

This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age> 18 years
• Moderate or severe ARDS
• Consent to participation obtained from a relative

Exclusion criteria

• Protect adult
• Pregnant or breastfeeding woman
• No-affiliation to the social security scheme
• Contra-indication to the placement of an esophageal pressure measuring catheter
• Pneumothorax
• Hemodynamic and / or respiratory instability
• Extra-corporeal membrane oxygenation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Arms A

Experimental group

Description:

Strategy 1 - Washout period - Strategy 2

Treatment:

Other: Strategy 1

Other: Strategy 2

Arms B

Experimental group

Description:

Strategy 2 - Washout period - Strategy 1

Treatment:

Other: Strategy 1

Other: Strategy 2