Comparison of Postoperative Anti-nausea and Vomiting Effect Between Glycopyrronium and Ondansetron

Chongqing Medical University

Status and phase: Unknown; Phase 4

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Ondansetron; Drug: Glycopyrronium

Study type: Interventional

Funder types: Other

Identifiers

NCT05265507

Glycopyrronium and ondansetron

Details and patient eligibility

About

To compare the anti-nausea and vomiting effect between glycopyrronium and ondansetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium to prevent postoperative nausea and vomiting.

Enrollment: 480 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists classification I-III
• Receive general anesthesia
• Voluntarily receive postoperative intravenous controlled analgesia

Exclusion criteria

• Puerpera or lactation women
• Allergy or existing contraindication to glycopyrronium and ondansetron
• Participate in other clinical drug trials within three months
• Can not follow with the study procedure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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480 participants in 2 patient groups

Glycopyrronium

Experimental group

Description:

Glycopyrronium (0.2mg) was intravenously given at the ending of the surgery.

Treatment:

Drug: Glycopyrronium

Ondansetron

Active Comparator group

Description:

Ondansetron (4mg) was intravenously given at the ending of the surgery.

Treatment:

Drug: Ondansetron