Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery

Pamukkale University

Status: Completed

Conditions: Hemorrhage; Pain, Postoperative; Wound Heal; Local Analgesia Via Infiltration

Treatments: Procedure: Free gingival graft (FGG); Drug: Articaine 4% with epinephrine 1:100,000; Drug: Lidocaine hydrochloride 2% with epinephrine 1:100 000

Study type: Interventional

Funder types: Other

Identifiers

NCT07145879

07.01.2025/01

Details and patient eligibility

About

The aim of this study is to compare and evaluate the effects of using lidocaine 2% (with adrenaline) and articaine 4% (with adrenaline) in free gingival graft (FGG) surgery on postoperative wound healing, changes in blood flow in the surgical area during the healing process, patients' postoperative pain levels, and anxiety levels before and after surgery.

Full description

In a prospective randomised controlled trial conducted to investigate the effect of lidocaine and articaine on postoperative free gingival graft healing, wound healing was assessed using EHS, anxiety was assessed using VAS, STAI, and MDAS questionnaires, and ultrasonographic evaluations and PI measurements were used to determine whether there was a difference in wound healing between the two anaesthetics.

Enrollment: 43 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients> 18 years requiring FGG surgery with ≤ 1 mm width of attached gingiva
• No systemic diseases or pregnancy.
• Smoking ≤10 cigarettes/day
• Full-mouth plaque score and full-mouth bleeding score ≤10% (four sites per tooth).
• Need for FGG due to insufficient attached gingiva
• No history of mucogingival or periodontal surgery at experimental sites

Exclusion criteria

• Use of oral contraceptives, psychotropic drugs, sedatives, or NSAIDs
• Allergy or hypersensitivity to local anesthetics,
• Orofacial neurological symptoms,
• Active infection in the surgical area,
• Pathological mental conditions such as dementia or psychosis, or lack of cooperation,

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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43 participants in 2 patient groups

lidocaine HCL

Other group

Description:

Participants will receive lidocaine HCL 2% with adrenaline for local anesthesia before free gingival surgery once only

Treatment:

Drug: Lidocaine hydrochloride 2% with epinephrine 1:100 000

Procedure: Free gingival graft (FGG)

articaine HCL

Other group

Description:

Participants will receive articaine HCL 4% with adrenaline for local anestesia before free gingival surgery once only

Treatment:

Drug: Articaine 4% with epinephrine 1:100,000

Procedure: Free gingival graft (FGG)