Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia

Army Medical University of People's Liberation Army

Status and phase

Completed

Phase 4

Conditions

Postoperative Cognitive Dysfunction

Treatments

Drug: propofol

Drug: sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02931877

Li Hong-Group

Details and patient eligibility

About

As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome. Most patients will receive general anesthesia and cardiopulmonary bypass (CPB) during cardiac valvular surgery. Inhalation sevoflurane based and propofol based anesthesia are most commonly used strategy for general anesthesia. At present, it was unknown that which one is better in providing cerebral protection effect for patients undergoing cardiac valvular surgery with CPB. The current study aimed to explore the possible difference.

Full description

The investigators hypothesize that the incidence of postoperative cognitive dysfunction (POCD) is not different in patients received intravenous anesthetics propofol or sevoflurane for their cardiac valvular surgery. Two groups of general anesthetics (propofol or sevoflurane) are used to explore the possible difference of the postoperative outcome and the incidence of POCD. After cardiac valvular surgery with CPB, patients' POCD tests at 7 days after the surgery, and postoperative delirium, etc., are evaluated by different questionnaires. Also the blood sample of these patients are collected for detection of some stress hormones.

Enrollment

300 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

patients who receive cardiac valvular surgery
18 to 65 years
American society of anesthesiologists classification Ⅱto Ⅲ
education level higher than elementary school

Exclusion criteria

Patients are not expected to be alive for longer than 3 months.
Mini-mental State Examination (MMSE) score ≤ 23.
current use of sedatives or antidepressant
history of dementia, psychiatric illness or any diseases of central nervous system.
accompanying liver or kidney function deficiency
history of some endocrine disease
alcoholism and drug dependence
patients previously included in this study or currently included in the other clinical study
patients who have second surgery during the study period
difficult to follow up or patients with poor compliance