Comparison of Postoperative Outcome of Hepatectomy for Living Donors According to Three Different Incision

Samsung Medical Center

Status: Completed

Conditions: Healthy Donors for Liver Transplantation

Treatments: Procedure: hepatectomy midline incision; Procedure: hepatectomy transverse incision; Procedure: hepatectomy conventional incision

Study type: Observational

Funder types: Other

Identifiers

NCT02413983

2015-01-016-002

Details and patient eligibility

About

Living donor liver transplantation (LDLT) is an important option for patients with end-stage liver disease requiring liver transplantation. When performing LDLT, the safety and well being of donors is of the utmost importance. The conventional incision for donor hepatectomy is a right subcostal incision with a midline extension up to xiphoid. Minimally invasive liver surgery throughout a single 10 cm upper midline incision without laparoscopic assistance has been widely applied and considered to be safe and effective. Recently, laparoscopic and minimally invasive living donor hepatectomy via transverse incision has been suggested to reduce morbidity and the invasiveness of living donor hepatectomy. Although minimally invasive approach has become the surgical method of choice for many transplant centers, little data on comparing the impact of all three different type incision in living liver donors. In our center, the investigators have adopted three different incision according to surgical teams. The investigators undertook this study with the aims of comparing the pain and quality of life of donors according to type of three different incisions and assessing any benefits to the donor due to the smaller midline incision during the early postoperative period.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA (American Society of Anesthesiologists) physical status I-II,
• adult undergoing hepatectomy for living donors

Exclusion criteria

• known allergy to any of the drugs used in this study,
• bleeding diathesis,
• neurologic dysfunction (preexisting lower limb neurological deficit),
• recent systemic or local infections,
• history of drug use, or
• under treatment with opioids because of chronic pain

Trial design

60 participants in 3 patient groups

CI (conventional incision)

Description:

The living liver donors underwent hepatectomy using right subcostal incision with a midline extension (conventional incision)

Treatment:

Procedure: hepatectomy conventional incision

MI (midline incision)

Description:

The living liver donors underwent hepatectomy using upper midline incision (10cm) without laparoscopic assistance

Treatment:

Procedure: hepatectomy midline incision

TI (transverse incision)

Description:

The living liver donors underwent hepatectomy using transverse incision with laparosocpic assistance

Treatment:

Procedure: hepatectomy transverse incision