Comparison of Postoperative Recovery Between TIVA and Inhalation Agent

Seoul National University

Status: Completed

Conditions: Enhanced Recovery After Surgery

Treatments: Drug: total intravenous anesthesia with propofol; Drug: inhalation anesthesia with desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT04447105

2003-177-1113

Details and patient eligibility

About

This prospective, randomized, single-blinded study is designed to compare the postoperative quality of recovery between propofol based total intravenous anesthesia and desflurane in patients undergoing minimally invasive nephrectomy. We hypothesize that propofol based total intravenous anesthesia can significantly improve the quality of recovery after surgery in patients with minimally invasive nephrectomy.

Full description

Adult patients undergoing elective laparoscopic or robotic assisted nephrectomy are randomly allocated to receive propofol based total intravenous anesthesia (n=75) or desflurane (n=75). The quality of recover after surgery using the QoR-15K was assessed by a investigator at postoperative day (POD) 1, 2, and 3. The primary outcome is the QoR-15K at POD 1, 2, and 3 after surgery.

Enrollment: 150 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled to undergo elective laparoscopic or robotic assisted nephrectomy under general anesthesia
• American Society of Anesthesiologists (ASA) physical classification I-II
• Willingness and ability to sign an informed consent document

Exclusion criteria

• Do not understand our study
• American Society of Anesthesiologists (ASA) physical classification III or more
• Allergies to anesthetic or analgesic medications
• Chronic pain, chronic analgesic or antidepressant or anticonvulsant use
• Medical or psychological disease that can affect the treatment response
• Patients who receive mechanical ventilation more than 2 hours after surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

150 participants in 2 patient groups

TIVA group

Experimental group

Description:

Patients receiving total intravenous anesthesia with propofol.

Treatment:

Drug: total intravenous anesthesia with propofol

Desflurane group

Active Comparator group

Description:

Patients receiving inhalation anesthesia with desflurane.

Treatment:

Drug: inhalation anesthesia with desflurane