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Comparison of Postoperative Recovery Between TIVA and Inhalation Agent

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Seoul National University

Status

Completed

Conditions

Enhanced Recovery After Surgery

Treatments

Drug: total intravenous anesthesia with propofol
Drug: inhalation anesthesia with desflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT04447105
2003-177-1113

Details and patient eligibility

About

This prospective, randomized, single-blinded study is designed to compare the postoperative quality of recovery between propofol based total intravenous anesthesia and desflurane in patients undergoing minimally invasive nephrectomy. We hypothesize that propofol based total intravenous anesthesia can significantly improve the quality of recovery after surgery in patients with minimally invasive nephrectomy.

Full description

Adult patients undergoing elective laparoscopic or robotic assisted nephrectomy are randomly allocated to receive propofol based total intravenous anesthesia (n=75) or desflurane (n=75). The quality of recover after surgery using the QoR-15K was assessed by a investigator at postoperative day (POD) 1, 2, and 3. The primary outcome is the QoR-15K at POD 1, 2, and 3 after surgery.

Enrollment

150 patients

Sex

All

Ages

19 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled to undergo elective laparoscopic or robotic assisted nephrectomy under general anesthesia
  • American Society of Anesthesiologists (ASA) physical classification I-II
  • Willingness and ability to sign an informed consent document

Exclusion criteria

  • Do not understand our study
  • American Society of Anesthesiologists (ASA) physical classification III or more
  • Allergies to anesthetic or analgesic medications
  • Chronic pain, chronic analgesic or antidepressant or anticonvulsant use
  • Medical or psychological disease that can affect the treatment response
  • Patients who receive mechanical ventilation more than 2 hours after surgery

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

150 participants in 2 patient groups

TIVA group
Experimental group
Description:
Patients receiving total intravenous anesthesia with propofol.
Treatment:
Drug: total intravenous anesthesia with propofol
Desflurane group
Active Comparator group
Description:
Patients receiving inhalation anesthesia with desflurane.
Treatment:
Drug: inhalation anesthesia with desflurane

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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