Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery

Chinese Academy of Medical Sciences & Peking Union Medical College

Status and phase: Completed; Phase 4

Conditions: Pituitary Adenoma

Treatments: Drug: sevoflurane; Drug: propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT05822817

K3501

Details and patient eligibility

About

Currently, total intravenous anesthesia (TIVA) and inhaled anesthesia are both commonly used for transsphenoidal pituitary adenoma resection. However, optimal choice for anesthesia maintenance in transsphenoidal surgery remains unclear. Previous studies focusing on this question provided fragmentary assessment and controversial results. The goal of this clinical trial is to investigate whether propofol and sevoflurane have different effect on post-anesthetic recovery after transsphenoidal resection of pituitary adenoma.

Enrollment: 252 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Men or women, aged from 18 to 70
2. American Society of Anesthesiologists (ASA) class I - III
3. Patients scheduled for transsphenoidal surgery requiring general anesthesia managed with endotracheal intubation

Exclusion criteria

1. Patients allergic or contraindicated to sevoflurane, propofol, or other drugs used during surgery
2. Severe pulmonary disease, saturation of peripheral oxygen (SpO2) < 90%
3. Severe nervous system disease with consciousness disorder
4. Patients scheduled for intensive care unit (ICU) after surgery
5. Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

252 participants in 2 patient groups

sevoflurane

Experimental group

Description:

Anesthesia is maintained with sevoflurane.

Treatment:

Drug: sevoflurane

propofol

Experimental group

Description:

Anesthesia is maintained with continuous infusion of propofol.

Treatment:

Drug: propofol