Comparison of Postprandial Inflammation in Lean and Obese Subjects

Agroscope Liebefeld-Posieux Research Station ALP

Status and phase: Completed; Early Phase 1

Conditions: Nutritional Intervention; Obesity; Nutritional and Metabolic Diseases

Treatments: Dietary Supplement: High-fat meal

Study type: Interventional

Funder types: Other

Identifiers

NCT01446068

NUTRICHIP-1

Details and patient eligibility

About

The purpose of this study is to quantify the systemic inflammatory and metabolic response of lean subjects and obese subjects to the ingestion of three caloric doses of a high-fat meal.

Enrollment: 36 patients

Sex: Male

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for lean subjects:

• age 25-50
• 20<BMI<25
• waist circumference <94cm

Inclusion Criteria for obese subjects

• age-matched to healthy subjects
• 30<BMI<40
• waist circumference >102cm

Exclusion Criteria for lean and obese subjects:

• Physiological or psychological diseases
• Allergies to food or intolerance to high-fat meal
• Vegetarians
• Chronic intake of drugs
• Smokers
• Diabetes mellitus Type I and II
• Debilitating kidney diseases
• Debilitating liver diseases
• Clinically established coronary heart diseases
• Ingestion of vitamins or dietary supplements during the course of the study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Lean Subjects

Experimental group

Treatment:

Dietary Supplement: High-fat meal

Obese subjects

Experimental group

Treatment:

Dietary Supplement: High-fat meal