Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic

Muhammad Aamir Latif

Status

Completed

Conditions

Orthopedic Surgery

Treatments

Drug: Pregabalin

Drug: Gabapentin

Study type

Interventional

Funder types

Other

Identifiers

NCT07389551

Dr-Usman-QAMC

Details and patient eligibility

About

There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.

Full description

Since postoperative pain in orthopedic surgery, whether neuropathic or nociceptive, presents a significant challenge for both surgeons and patients, knowing the more effective gabapentinoid as a pre-emptive analgesic would help clinicians to offer prolonged timing of first rescue analgesia and less opioid consumption.

Enrollment

142 patients

Sex

All

Ages

20 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Either gender
Aged 20-60 years
Undergoing lower limb orthopedic surgeries under spinal anesthesia

Exclusion criteria

Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief
Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation
Patients had a long-term history of any analgesia use
Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities,
With a history of allergies to gabapentinoids